Ewan, Charley, and the team land in Ushuaia, the southernmost tip of South America, but tensions arise due to snow and mechanical issues. Traveling 13000 miles over 100 days on electric bikes is hard to imagine. Ewan McGregor and Charles Boorman find out how challenging their mission is as they embark on a journey on prototype Harley Davidsons and the Rivian trucks. The first obstacle is electricity. While parts of the city have no problems with charging the bikes and the trucks, the countryside is where the duo face issues.

Ewan McGregor and Charley Bormann are very close to finishing their journey. Discussions on security are still on the agenda; they cannot travel at night due to dangerous cartels. They will need to do many miles on a bus with space for the bikes inside. The team manage to get the bikes on after concerns they wouldn’t fit. Repairing and conditioning the bus is an achievement considering they did it in a few days.
Ewan and Charley get back on their bikes, and they head to their last border cross to enter the United States. After 12 hours in the border, the crew, Ewan and Charley make it to America. It’s an easy stretch to L.A. on their bikes. Ewan, the crew and family, finish the last leg. It’s done, they’ve managed to finish Long Way Up. It’s such an achievement. Episode 11 is a heartfelt finale, showcasing the end of an incredible journey from both Ewan, Charley, and the team that supported them.

Ewan McGregor and Charley Boorman, after more than a decade since their last motorbike adventure around the world, will cover 13,000 miles over 100 days through 13 countries. Starting from the city of Ushuaia at the tip of South America, Ewan and Charley travel through the glorious and underexposed landscapes of South and Central America to Los Angeles in the United States in their most challenging expedition to date. In their journey they will use cutting-edge technology on the backs of their prototype electric Harley-Davidsons in order to contribute to the sustainability of the planet.
In the first episode, Ewan McGregor reunites with his best friend Charley Boorman to evaluate what's important in their lives, following a life-threatening accident of Charley.

The fourth episode starts off with the two riding through Santa Cruz, Argentina. The plan is to cross over into Chile and then going up into the Andes. Ewan and Charley head through Argentina’s red rock landscape while a member of their team copes with altitude sickness. The duo are well and truly underway and the first signs of all are well is how well the Harleys hold up in challenging conditions. The roads alternate between unforgiving and pleasant and these e-bikes push through effortlessly. As they ride through Chilean Andes, the audience is shown a picturesque view of the beauty of the countryside, an experience which Boorman calls 'magical.'

As the journey continues, there's beauty and danger in equal measure for Charley Boorman and Ewan McGrego. The duo ride their electric Harleys through the exotic and breathtaking Bolivian countryside in a tough ascent. The sixth episode showcases some of the challenges the hosts and the crew face when they scale the terrain. One of the Rivians runs into trouble while sandy roads and a heavy breeze sees Boorman take a tumble. Apart from all the accidents, the chapter also shows some quality work done by UNICEF when it comes to educating and working with the children in Bolivia.
The altitude sickness hits Taylor, their logistics man real bad and McGregor starts feeling it as well. The episode ends with a doctor heading to his hotel room to check up on him.

As the journey continues, there's beauty and danger in equal measure. Charley and Ewan travel through the extraordinary Bolivian desert, but the sandy roads make all more difficult. The duo ride their electric bikes through the exotic and breathtaking countryside and all the way making a challenging ascent. The riders stay in a hotel made entirely out of salt before heading to La Paz. 'Bolivia' also shows some quality work done by UNICEF when it comes to educating and working with the children. McGregor and Boorman spend time with the kids before resuming their journey and ending with a ferry ride over lake Titicaca.