In the second stop in his exploration of the wonders of the universe, Professor Brian Cox goes in search of humanity's very essence to answer the biggest questions of all: what are we? And where do we come from? This film is the story of matter - the stuff of which we are all made. Brian reveals how our origins are entwined with the life cycle of the stars. But he begins his journey here on Earth. In Nepal, he observes a Hindu cremation. Hindu philosophy is based on an eternal cycle of creation and destruction, where the physical elements of the body are recycled on to the next stage. Brian draws a parallel with the life cycle of the stars that led to our own creation. Next, he explains how the Earth's resources have been recycled through the ages. How every atom that makes up everything we see, was at some time a part of something else. Our world is made up of just 92 elements, and these same 92 elements are found throughout the entire universe. We are part of the universe because we are made of the same stuff as the universe.

In the final part, Professor Al-Khalili uncovers tales of success and heartache in the story of chemists' battle to control and combine the elements, and build our modern world. He reveals the dramatic breakthroughs which harnessed their might to release almost unimaginable power, and he journeys to the centre of modern day alchemy, where scientists are attempting to command the extreme forces of nature and create brand new elements.

The simple act of making an apple pie is extrapolated into the atoms and subatomic particles (electrons, protons, and neutrons) necessary. Many of the ingredients necessary are formed of chemical elements formed in the life and deaths of stars (such as our own Sun), resulting in massive red giants and supernovae or collapsing into white dwarfs, neutron stars, pulsars, and even black holes. These produce all sorts of phenomena, such as radioactivity, cosmic rays, and even the curving of spacetime by gravity. Cosmos Update mentions the supernova SN 1987A and neutrino astronomy.

To survive, animals need somewhere to live, a place that provides the necessities of life, shelter from the elements and a refuge from enemies. Good homes are rare and competition can be intense – finding a home is one thing, but defending it is quite another.

In this episode, Michael demonstrates how our society is built on our search to find the answer to what makes up everything in the material world. This is a story that moves from the secret labs of the alchemists and their search for gold by the stone of the philosophers to the creation of the world's first synthetic dye - Purple - and onto the invention of the transistor. This quest may seem abstract and highly theoretical. Yet it has delivered the greatest impact on humanity. By trying to answer this question, scientists have created theories from elements to atoms, and the strange concepts of quantum physics that underpin our modern, technological world.

After 400 BC, a new philosophy was born in South east Asia, generated from the ideas of Buddha, a mysterious Prince from India who gained enlightenment while he sat under a large, shapely fig tree. He remains one of the most legendary and influential of all religious progenitors, but what of his actual life? In this biographical documentary, director David Grubin tells the historical tale of Gautama Buddha (563-483 BC), from his initial enlightenment through his death around the age of 80. In the process, Grubin makes an unusual point: that Gautama never once claimed to be God or God's emissary, but instead sought to find a way to bring peace and alleviation from suffering to others in a cruel and often insane world. In telling this story, Grubin combines a number of elements including original animations, testimony by contemporary Buddhists such as the 14th Dalai Lama Tenzin Gyatso, glimpses of sculptures and paintings that help tell Gautama's story, and much more. Narrated by Richard Gere