Brian Cox looks at our attempts to answer one of the most profound questions we can ask – are we alone in the universe? With scientists sending space probes to the furthest reaches of our solar system and beyond, the scientific search for alien life has begun. Inspired by a childhood love of science fiction, Brian still hopes to hear from ET. In this film, he explains why this search deserves to be taken seriously, and he explores the chances of it happening.

The cosmos, with its billions of galaxies and countless stars, isn't the only one. We share our lives with another universe: The world of the small, of the viruses, of the bacteria. We call this strange hidden kingdom the Microcosmos. We share our world with the microcosmos. Will we coexist in an uneasy peace, or will it destroy us?
In 2020, A tiny virus caused a global pandemic, COVID-19. This pandemic makes people see the world completely differently, because there was an invisible universe, pretty much ignored for the most part. Very, very tiny things have a huge impact on our lives. The microcosmos is complex, while some parts kill us, others keep us alive. The microcosmos is responsible for the very oxygen that we breathe and the soil on which we live. And it will influence our future as we venture out into space.

NASA's brand-new Mars rover is on the hunt for alien life, and with the help of cutting-edge engineering, scientists embark on a search for fossilized remains, which might prove the Red Planet was once home to a vast ocean and extraterrestrial life. Perseverance carries seven scientific instruments to study the Martian surface at Jezero crater. It carries several cameras and two microphones. The rover is accompanied by the helicopter Ingenuity, which will help Perseverance to scout for locations to study.

The series, depicted by state of the art CGI techniques, and applying the laws of life on Earth to the rest of the galaxy, blends fact with science fiction and conceptualizes what alien life might be like on other planets.
In the prologue, astronomer Didier Queloz makes an appearance to discuss the discoveries of exoplanets and how they are analyzed in the real world. In Episode 1, the fictional world imagined is Atlas, a world with higher gravity than Earth and a thicker atmosphere leading to airborne creatures. In explaining the aliens of Atlas, the episode also explores the handicap principle in insects, and shows a rehabilitative form of falconry as captive falcons are trained to live in the wild.

Where is everyone? We have been listening for messages from outer space for more than half a century, and so far... silence, why? Are we truly alone in the universe? Or is everyone else acting like us and just doing a lot of listening? Maybe we need to be louder. Maybe we need to send more messages out there. But how do you write a letter to an extraterrestrial whose language and culture and biology and mind we have no concept of? And what do you say?
Given all of the unknowns about what they might behave, should we say anything at all?

Quinto sets out to discover whether aliens exist and what evidence we have to prove it. He meets with several who say they have encountered extra-terrestrial life–a man who has been abducted by aliens several times since childhood; a man who claims to have extracted an alien implant; and a woman who shows Zachary what it feels like to be abducted into a spacecraft.
Zachary also meets with the world's leading scientists at SETI in Green Banks, West Virginia. There, utilizing the world's largest telescope, they show him the methods they employ to communicate with potential other-worldly visitors and what this research has taught them about a mysterious radio signal they picked up 3 billion light years away.