An epic documentary film in which nine scientists will meet in a chain of encounters to uncover unexpected answers to some of humanity's biggest questions. How did life begin? What is time? What is consciousness? How much do we really know? By introducing researchers from diverse backgrounds for the first time, then dropping them into new, immersive field work they previously hadn't tackled, the film reveals the true potential of interdisciplinary collaboration, pushing the boundaries of how science storytelling is approached.
What emerges is a deeply human trip to the foundations of discovery and a powerful reminder that the unanswered questions are the most crucial ones to pose. The Most Unknown is an ambitious look at a side of science.

Most planets we know of are so hellish, it seems impossible that anything could live. But it's amazing where life can take hold in the Earth. Astrobiologists look for simple single-celled microbes known as extremophiles in places as Danakil Depression, known in Ethiopia as 'The Gateway to Hell.'
In Episode 2, the fictional world is Janus, a planet in such a close orbit than its rotation is locked by the star's gravity and it always shows the same face to its sun. On one side of the planet, it's always daytime, a searing desert. On the other side, it's forever night, a frozen shadowland. Squeezed between the two, a sliver of perpetual twilight. Freezing meltwater flows from the cold side, carving canyons through the landscape. Deep in these canyons lives an extraordinary five-legged creature.

In the third episode, the discovery of extraterrestrial life might face an impossible challenge: the physics of the universe itself; but using cutting-edge tech, experts might be on the verge of a groundbreaking find -- and the evidence could already be in hand.

Brian Cox looks at our attempts to answer one of the most profound questions we can ask – are we alone in the universe? With scientists sending space probes to the furthest reaches of our solar system and beyond, the scientific search for alien life has begun. Inspired by a childhood love of science fiction, Brian still hopes to hear from ET. In this film, he explains why this search deserves to be taken seriously, and he explores the chances of it happening.